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Archive for September, 2008

Sex Eases Pain of Arthritis at 70

September 30th, 2008 -- Posted in Arthritis / Joint Pain, Physical Health | No Comments »

In a new study, researchers found that today’s 70-year-olds are having more sex  and enjoying more satisfying sex — than ever before .The study, from Gothenburg University in Sweden, showed that self-reported levels of sexual satisfaction among 70-year-olds in Gothenburg has been on the rise, from 58 percent of 70-year-old men reporting satisfaction in 1976-77 to 71 percent reporting sexual satisfaction in 2000-01. Among women, the increase was from 41 percent to 62 percent during the same period.

“There is no question that people in their 70s today are like people in their 60s from the last decade,” said Judith Kuriansky, a clinical psychologist, sex therapist and faculty member at Columbia University Teachers College.

Because the study was based on interviews, it is subject to the honesty of the septuagenarians who were interviewed, but even if this is merely a rise in talking about sex rather than actual sex that is on the rise, Kuriansky sees that alone as a positive. “If they’re more comfortable talking about it, they’re more comfortable doing it,” she said.

The longer life spans of women can prevent many from having partners late in life, but Kuriansky said she has a suggestion for women facing that problem. “Sex therapists like myself encourage people to be self-pleasuring,” she said. “If you have no partner, you can continue to be pleasured by yourself.” Kuriansky said that the sexual climaxes have the added benefit of easing the pains associated with arthritis. The article, “Study Shows Sexual Satisfaction at 70 Improving” appeared at July 10th on the website “ABC News”

Source: Teacher’s College, Columbia University (http://www.tc.columbia.edu/news/article.htm?id=6686)

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Restless nights put older adults at risk for depression recurrence

September 30th, 2008 -- Posted in Life Extension, Mental Health | No Comments »
Nearly 60 percent of the nation’s elderly have trouble sleeping, whether it’s a lot of tossing and turning or outright bouts of insomnia. While for most people sleeplessness can be annoying at best or unhealthy at worst, for elderly individuals who have suffered from depression in the past, poor sleep may be the first sign that a new bout of depression is coming on.
In a study to be published in an upcoming issue of the American Journal of Psychiatry and currently available online, UCLA professor of psychiatry Dr. Michael Irwin and his colleagues posed three hypotheses: risk for depression would be higher among older people with a prior history of the disorder; among those with prior depression, sleep disturbance could predict a relapse or recurrence; and sleep disturbances could act as a risk factor for depression recurrence separate from other depressive symptoms. The study confirmed all three hypotheses.
“Insomnia is the most frequent sleep disturbance in depressed patients and is viewed as a symptom of current depression,” said Irwin, who also directs the Cousins Center for Psychoneuroimmunology at UCLA’s Semel Institute for Neuroscience and Human Behavior. “But when sleep disturbances begin to emerge in an otherwise healthy adult who has experienced depression in the past, we found that it may serve as a precursor to another attack of depression.”
The study looked at 351 adults, age 60 and older. Of that number, 145 had a prior history of major or non-major depression that was in full remission, while 206 had no prior history of depression or other mental illness. The participants were assessed at four different times over a two-year period for depressive episodes, depressive symptoms, sleep quality and chronic medical disease.
The researchers found that of the subjects with prior depression, 23 had a relapse, compared with only one person in the group without prior mental illness. With the first group, researchers were able to predict depression recurrence based on individuals’ sleep disturbance. Irwin noted that this association was established independently of other depressive symptoms, chronic medical disease or any use of antidepressants.
The study, Irwin said, is the first to demonstrate that sleep disturbances act as an independent risk factor for depression recurrence in older adults.
“Unfortunately, sleep difficulties are often considered to be a part of normal aging, and asking about and assessing the quality of an older person’s sleep is frequently overlooked during routine doctor visits,” Irwin said. “The omission is particularly striking, since we know that sleep disturbance is associated with declines in health functioning and with increases in all causes of mortality in older adults.
“And now, this study shows that sleep disturbance is often related to depressive disorders in late life, which carry further considerable risks for morbidity and mortality.”
To identify older adults at risk for depression, Irwin said, a two-step strategy can be employed. One step involves assessment of whether individuals have had a prior episode of depression, the other whether they have current and ongoing sleep disturbance.
“Given that sleep disturbance is a modifiable risk factor,” he said, “these findings tell us that we need to develop treatments that target sleep disturbances for the prevention of depression recurrence in older adults.”
In addition to Irwin, other authors of the study included Hyong Jin Cho, M.D., Ph.D.; Helen Lavretsky, M.D.; Richard Olmstead, Ph.D.; Myron J. Levin, M.D.; and Michael N. Oxman, M.D.
Levin reports receiving funds from pharmaceutical company Merck & Co. Inc. The other authors report no competing interests.
Funding for the study was provided by grants from the National Institute on Aging, the National Institute of Mental Health; and the Cooperative Studies Program of the U.S. Veteran’s Affairs Office of Research and Development.
Source: UCLA Newsroom, Mark Wheeler (http://www.newsroom.ucla.edu/portal/ucla/restless-nights-puts-older-adults-64185.aspx)

Cutting calories could limit muscle wasting in later years

September 18th, 2008 -- Posted in Physical Health | No Comments »

Chemical concoctions can smooth over wrinkles and hide those pesky grays, but what about the signs of aging that aren’t so easy to fix, such as losing muscle mass? Cutting calories early could help, say University of Florida researchers who studied the phenomenon in rats.A restricted-calorie diet, when started in early adulthood, seems to stymie a mitochondrial mishap that may contribute to muscle loss in aging adults, the researchers reported recently in the journal PLoS One.

In rats, the scientists found pockets of excess iron in muscle cell mitochondria, the tiny power plants found in every cell. The excess iron affects the chemistry inside the mitochondria, sparking the formation of harmful free radicals that can lead a mitochondrion straight to the emergency exit, said Christiaan Leeuwenburgh, a UF professor of aging in the UF College of Medicine and the Institute on Aging. Leeuwenburgh was the senior author of the study and of a related report published online this month in Aging Cell that details the damage done by excess iron in mitochondria.

“We become less efficient at an old age and we need to understand why this is,” Leeuwenburgh said. “One thing, maybe, is the accumulation of redox-active metals in cells. If the mitochondria become unhappy or are ready to kick the bucket, they have proteins in the inner and outer membranes that they can open up and commit suicide. They’re tricky beasts.”

The suicidal mitochondria can damage the rest of the muscle cell, leading to cell death and perhaps to muscle wasting, a big problem for adults as they reach their mid-70s, Leeuwenburgh added.

“Muscle is critical for your overall well-being,” Leeuwenburgh said. “As you walk, muscle functions partly as a pump to keep your blood going. Muscle is an incredible source of reserves.”

The researchers found increasing amounts of iron in the muscle cells of aging rats fed a typical unrestricted diet. The older the rats got, the more iron accumulated in the mitochondria and the more damage was done to its RNA and DNA. Rats of the same ages that were kept on a calorie-restricted diet — about 60 percent of the food typically ingested — seemed to maintain more normal iron levels in mitochondria, the researchers reported.

“The novel thing here is that iron is accumulating in places it does not normally accumulate,” said Mitch Knutson, a UF assistant professor of food science and human nutrition and a study co-author. “Such iron accumulation in muscle was quite unexpected. This may be of concern because more people are genetically predisposed to developing iron overload than we originally thought.”

The problem occurs when metals such as iron accumulate in the mitochondria and react with oxygen. Iron can change the chemical structure of oxygen, triggering its metamorphosis into a free radical, an unstable atom that can upset the delicate balance inside the mitochondria. The result? Leeuwenburgh describes it sort of like internal rust.

“Not all free radicals are harmful,” Leeuwenburgh said. “To just use antioxidants to neutralize all free radicals is a huge misconception because some radicals are helpful. You just need to try and target very specific free radicals that form in specific parts of the body.”

Researchers don’t know exactly what causes iron to accumulate in mitochondria in aging animals, but a breakdown in how iron is transported through cells could be one reason why, Leeuwenburgh said. Understanding how caloric restriction limits the problem in rats could help researchers better understand how to combat it, he added.

Russell T. Hepple, an associate professor of kinesiology and medicine at the University of Calgary in Canada, said the findings are another step forward in linking iron to muscle cell death, but there are more questions researchers must answer.

“They’ve shown that apoptosis (cell death) goes up in aging muscle but where does that happen?” Hepple asked. “There are more than muscle cells in muscle. (For example) in older adults there are inflammatory cells.”

Source: University of Florida (http://news.ufl.edu/2008/09/16/iron-link/)

Choose a healthy lifestyle to keep your brain in peak shape!

September 10th, 2008 -- Posted in Brain Food, Mental Health | 1 Comment »

The brain is like any other muscle in the body that gets stronger with proper exercise and shrivels if neglected. To keep the brain functioning at its full potential, researchers say there are specific lifestyle adjustments which can be made that can benefit many important brain functions.

Memory, one of the pivotal functions the brain performs, can be enhanced by staying mentally active, eating right, and participating in some form of physical exercise on a daily basis.

Mental exercise

Working out the mind with strategies to increase memory capacity are not just for the aging, but can also be used by the younger generations for some short-term payoffs, UCLA memory researchers said.

Recent studies have found that after normal adults are thought to use these strategies for remembering, their brain activity has become more efficient according to scans, said Gary Small, professor of clinical psychiatry at UCLA.

These mental exercises can be easily remembered as the “look, snap and connect,” Small said.

The first step in remembering is to look and focus your attention on your subject, he added.

“You should never multitask since it hurts your ability to attend to information and will cause you not to remember,” Small said.

The next step, snap, involves creating a visual image of the subject matter that you are trying to remember, he added. This helps to recall and retrieve the information later.

Medical school students often use these sorts of techniques when required to memorize complex anatomy, said Linda Ercoli, director of geriatrics psychology at the UCLA Semel Institute.

“The idea is to associate them with things that you already know that have meaning for you,” Ercoli said. “This will allow the processing to happen on a more meaningful level.”

The final step is to connect, which consists of putting the newly learned information into context, Small said.

“If you just memorize facts, it will be in and out,” Small said. “You need to rehearse and repeat the information; a good way to do this in class is to take good notes in class and write summaries after.”

If strategies like this are applied to everyday life, people can bring their memory abilities up to their full potential and even prevent future degenerative conditions of the brain, Small added.

Diet

The brain is affected by everything you put into your body, including your diet.

Recent studies have found that a well-balanced diet can help ward off the appearance of all kinds of mental disorders, including those that involve memory loss like Alzheimer’s.

Fernando Gomez-Pinilla, professor of neurosurgery at UCLA, analyzed 160 studies to understand how food can impact the brain.

“The basic idea of the research is that the capacity of the brain depends on the type of life we have,” Gomez-Pinilla said. “Essentially, the simple things we do may have an important influence on the brain.”

It was discovered that omega-3 fatty acids, found in salmon, kiwi, and walnuts can improve memory abilities and prevent mental disorders as well.

Gomez-Pinilla focused also on the synapses in the brain, which connect brain cells, where it is believed learning and memory occur.

Another study found that children exposed to a diet rich with this brain vitamin, omega-3, performed better in school and had fewer behavioral problems.

Other brain enriching foods include spinach, rich with folic acid which is essential for brain function, Gomez-Pinilla said.

There are foods to stay away from that can cause damage to many systems in the brain, including memory, Gomez-Pinilla said.

Junk foods that are high in saturated fats have been shown to negatively impact the synapses of the brain, he added. Certain fruits, like blueberries, have the opposite effect since they are rich antioxidants and prevent oxidative damages which accumulate in the brain.

Healthy diets are essential not only for physical well-being, but also for the mind, Gomez-Pinilla said.

Exercise and stress

Getting your blood pumping through exercise has been linked to increased brain function and memory.

Several studies using animal models have found exercise can help increase cognitive function in animals as well as reduce the mental decay which occurs with aging, said Fernando Gomez-Pinilla, professor of neurosurgery at UCLA.

“Doing 30 minutes of running exercise a day can make a big short-term difference in memory and mental function,” Gomez-Pinilla said.

The best type of exercise is cardiovascular since it is good for the heart, hence good for the brain, said Gary Small, professor of clinical psychiatry at UCLA.

This form of exercise, like running, gets more blood flowing to the brain, he added.

However, there may be other reasons why exercise has been shown to work wonders for getting the brain in shape.

The endorphin rush which hits the body during exercise may also be a brain-strengthening mechanism.

Other findings suggest that high amounts of stress, which release the stress hormone, cortisol, in to the body can interfere with memory production and storage, Small said.

In terms of test taking and study habits, Small said that cramming is one of the worst methods, especially due to the elevated levels of stress in addition to lack of sleep.

Small added that many students can get by fine cramming, partying on the weekends, and getting little or no sleep because the teenage years up to the early 20s are the prime time for learning and brain power.

But, cramming may work now, but it won’t a few years down the line, Small said.

So the time is now to start taking care of your memory, Small added.

Source: University of California, Los Angeles (http://www.dailybruin.ucla.edu/news/2008/sep/08/choose-healthy-lifestyle-keep-your-brain-peak-shap/)

Analysis of common brain tumor finds new gene mutations

September 4th, 2008 -- Posted in Mental Health, Physical Health | No Comments »

The most comprehensive-to-date genomic analysis of a cancer – the deadly brain tumor glioblastoma multiforme – shows previously unrecognized changes in genes and provides an overall view of the missteps in the pathways that govern the growth and behavior of cells, said members of The Cancer Genome Atlas Research Network in a report that appears online today in the journal Nature.

“This was a big thrust for the public project,” said Dr. Richard Gibbs, director of the Baylor College of Medicine Human Genome Sequencing Center, a member of the network and a co-author of the paper. “This answers the big question about whether the cancer genome project is worthwhile. The results show that it is—definitely.” The BCM center, the Genome Sequencing Center at Washington University School of Medicine in St. Louis, Mo., and the Broad Institute of MIT and Harvard in Cambridge, Mass., led the effort that included many members from across the nation.

Analysis reveals important clues

This interim analysis of 91 tumors and 623 genes provides important clues about how the disease originates and progresses in cells and how it eludes the effects of potent anti-cancer drugs and radiation, said Dr. David Wheeler, associate professor in the Genome Sequencing Center and a co-author of the report. It could provide researchers with clues about how to treat the disease. The Baylor Human Genome Sequencing Center was a major component in the effort to sequence the genes and identify mutations and changes that affected the ways cells react.

“Studies like this show the breadth of mutation across many genes,” said Wheeler. “We can see the mutations in all the genes of each pathway that control growth, replication and death in the cancer cell. Researchers have never seen the whole landscape like this before, and it’s providing many new insights into strategies to diagnose and treat cancer.”

The ultimate goal of the project is to sequence the entire exome – that portion of the genetic blueprint that provides the code for proteins – of the tumor, said Wheeler. In fact, he said, the goal is to sequence genes in 500 brain cancer samples, but the network decided to publish preliminary results.

“When we pulled everything together with just 91 samples, the results were so interesting and important for treatment that we felt we should publish before the end of the project,” he said.

Glioblastoma is the most common primary brain tumor. Most people live approximately one year after diagnosis. Understanding this cancer could result in better forms of treatment.

Wider view of cell pathways

The analysis identified some genes known to cause cancer but whose role in glioblastoma had been previously underestimated, he said. For example, the genes ERBB2 (known to be implicated in breast and other cancers) and NF1 (neurofibromatosis gene 1 involved in a variety of tumors) were both found to be frequently mutated in this brain tumor. Other genes that previously had no known role in glioblastoma such as PIK3R1, a gene involved in regulating the metabolic actions of insulin were also found mutated in a variety of tumors.

In addition, the analysis gave scientists a wide view of how cell pathways are altered during the initiation and growth of glioblastoma.

“If we know what pathways are key to the formation of a tumor, we can design drugs to block those pathways,” said Wheeler. “In cancer, key pathways are co-opted to make the cell grow and divide in an uncontrolled fashion.”

For example, the TP53 pathway tells mutated cells to die in a process called apoptosis.

“It’s a fail-safe mechanism,” said Wheeler. “If a cell starts to become cancerous, p53 causes the cell to kill itself. If that pathway is knocked out, the cell avoids the fail-safe mechanism and can continue to divide.”

Other pathways involved in the sequencing effort are also disrupted to allow the cancer to grow, he said.

Funding for this work came from the National Institutes of Health.

Others who took part in the sequencing effort at BCM include Donna Muzny, Margaret Morgan, Steve Scherer, Aniko Sabo, Lynn Nazareth, Lora Lewis, Otis Hall, Yiming Zhu, Yanru Ren, Omar Alvi, Jiqiang Yao, Alicia Hawes, Shalini Jhangiani, Gerald Fowler, Anthony San Lucas, Christie Kovar, Andrew Cree, Huyen Dinh, Jireh Santibanez, Vandita Joshi, Manuel L. Gonzalez-Garay, Christopher A. Miller, Aleksandar Milosavljevic and Larry Donehower.

Other institutions involved in this work include the Dana-Farber Cancer Institute in Boston; Harvard Medical School and The Brigham and Women’s Hospital in Boston; Memorial Sloan-Kettering Cancer Center in New York; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore; the National Cancer Institute Center for Bioinformatics in Bethesda, Md; the University of North Carolina Lineberger Comprehensive Cancer Center in Chapel Hill; SRA International Inc., in Fairfax, Va.; HudsonAlpha Institute for Biotechnology in Huntsville, Ala.; Lawrence Berkeley National Laboratory in Berkeley, Calif., and the International Genomics Consortium in Phoenix, Ariz.

Source: Baylor College of Medicine (http://www.bcm.edu/news/item.cfm?newsID=1200)

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